Ĭompared with the MoCA, the MoCA-BC takes less time (the total number of tests is reduced by 3), and the change in some non-memory cognitive function tests improves the sensitivity for screening and the acceptance of the participants. The Chinese version of the MoCA-B (MoCA-BC), translated with cultural modifications from the original English version, has shown excellent validity and accuracy in distinguishing between NC, MCI, mild and moderate AD among the Chinese elderly with various levels of education. The cutoff points to detect MCI or AD have been demonstrated to be different all over the world. Several items in the MoCA incorporated tasks that showed wide differences due to formal education or literacy levels, such as the Trail-Making Test, cube copy, and naming low-familiarity animals. The Montreal Cognitive Assessment (MoCA) had been used as a quick evaluation scale to detect MCI in the group of highly educated elderly adults with an average education level of 13 years. There is a close relationship between MCI and AD. Neuropathology has found that MCI patients also had extracellular amyloid deposition and neurofibrillary tangles in the susceptible brain regions of AD patients (such as the olfactory cortex in the medial temporal lobe). Approximately 10–20% of adults over the age of 65 have MCI, and approximately 10% of these patients may progress to AD. Alzheimer’s disease (AD) is the most common neurodegenerative disease, and the incidence of AD increases with age. Mild cognitive impairment (MCI) is a transitional cognitive state between normal ageing and the early stages of dementia. Various items of the MoCA-BC can identify MCI patients early and identify the severity of dementia. The verbal fluency test was efficient for detecting MCI and differentiating AD severity. The delayed recall memory test had high sensitivity and specificity for MCI screening. The MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. Five MoCA-BC item scores were collected in interviews. NC ( n = 329) were recruited from health checkup outpatients.
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MCI ( n = 456), mild AD ( n = 502) and moderate-severe AD ( n = 102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China.
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To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD), as well as their sensitivity and specificity.